Publications

Only first- and corresponding-author publications from Gao lab members are listed below. See Google Scholar for a complete chronological list of papers and patents.

Original research, post-independence

LS Mille*^, JN Wang*, CL Driscoll*, H Dai*, TM Widatalla, X Zhang, BL Hie^, XJ Gao^.
Efficient generation of epitope-targeted de novo antibodies with Germinal
BioRxiv. 2025.

N Katz*, C An*, YJ Lee, J Tycko, M Zhang, J Kang, L Bintu, MC Bassik, WH Huang, XJ Gao.
Tunable, self-contained gene dosage control via proteolytic cleavage of CRISPR-Cas systems
BioRxiv. 2025.

NS Kolber, KE Kaseniit, TV Lanz, WH Robinson, XJ Gao.
Sequence-Independent RNA Sensing in Living Mammalian Cells
BioRxiv. 2025.

WS Lu*^, X Zhang*^, LS Mille, H Dai, XJ Gao^, WH Wong^.
ProVADA: Generation of Subcellular Protein Variants via Ensemble-Guided Test-Time Steering
BioRxiv. 2025.

AE Vlahos*^, CC Call*, N Eckman, SE Kadaba, S Guo, AR Thurm, J Kang, E Appel, L Bintu, XJ Gao^.
A complete suite for compact programming of protein secretion
BioRxiv. 2025.

E Wolfsberg, JS Paul, J Tycko, B Chen, MC Bassik, L Bintu, AA Alizadeh, XJ Gao.
Machine-Guided Dual-Objective Protein Engineering for Deimmunization and Therapeutic Functions
Cell Systems. 2025;16:101299. (pdf) (supp)

X Zhang*, LS Mille*, KE Kaseniit, AP Lee, M Zhang, CC Call, Y Hu, Y Xie, XJ Gao.
Post-Transcriptional Modular Synthetic Receptors
Nat Chem Biol. 2025;21:1250-1261. (pdf) (supp)
News & Views: H Hakariya & T Stafforst. Nat Chem Biol.

CA Aldrete*, CC Call*, LE Sant’Anna, AE Vlahos, J Pei, Q Cong, XJ Gao.
Orthogonalized human protease control of secreted signals
Nat Chem Biol. 2025;21:1351-1360. (pdf) (supp)

KE Kaseniit, N Katz, NS Kolber, CC Call, DL Wengier, WB Cody, ES Sattely, XJ Gao.
Modular, programmable RNA sensing using ADAR editing in living cells
Nat Biotechnol. 2023;41:482–487. (pdf) (supp)
Research Highlight: D Burgess. Nat Rev Genet. (pdf) | News: JD Grinstein. GEN Edge. (pdf)

AE Vlahos, J Kang, CA Aldrete, R Zhu, LS Chong, MB Elowitz, XJ Gao.
Protease-controlled secretion and display of intercellular signals
Nat Commun. 2022;13:912.


Original research, pre-independence

XJ Gao*, LS Chong*, MH Ince, MS Kim, MB Elowitz.
Engineering multiple levels of specificity in an RNA viral vector
BioRxiv. 2020.

XJ Gao*, LS Chong*, MS Kim, MB Elowitz.
Programmable protein circuits in living cells
Science. 2018;361(6408):1252-1258. (pdf) (supp)
Perspective: DS Glass, U Alon. Science. (pdf) | Research: LB Ray. Science. (pdf) | In Brief: N Rusk. Nat Methods. (pdf) | News and Views: Y Wu, Y Wang. Nat Chem Biol. (pdf) | Outreach: XJ Gao, LS Chong, MS Kim, MB Elowitz. Biomed Sci J Teens. (pdf)

B Wu*, L Luo^, XJ Gao*.
Cas9-triggered chain ablation of cas9 as a gene drive brake
Nat Biotechnol. 2016;34(2):137-138. (pdf)

XJ Gao^, O Riabinina, J Li, CJ Potter, TR Clandinin^, L Luo^.
A transcriptional reporter of intracellular Ca2+ in Drosophila
Nat Neurosci. 2015;18(6):917-925. (pdf) (supp)
Recommendation: YN Jan, S Meltzer. F1000.

XJ Gao^, TR Clandinin, L Luo.
Extremely sparse olfactory inputs are sufficient to mediate innate aversion in Drosophila
PLOS ONE. 2015;10(4),e0125986. (pdf)

XJ Gao, CJ Potter, DM Gohl, M Silies, AY Katsov, TR Clandinin^, L Luo^.
Specific kinematics and motor-related neurons for aversive chemotaxis in Drosophila
Curr Biol. 2013;23(13),1163-1172. (pdf) (supp)


Other writings

EL Chaikof, J Chen, MU Gillette… XJ Gao^, KE Galloway^
Integrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems
Cell Syst. 2025.

XJ Gao.
Induction

C An, N Katz, XJ Gao.
Designing quantitative gene therapy on ComMAND
Cell Syst. 2025.

X Zhang*^, LS Mille*^.
Enabling RNA-compatible synthetic receptors through RNA editing

XJ Gao.
Empower the age of smart mRNA medicine
Science. 2025;388(6742):40-41. (pdf)

CA Aldrete*, C An*, CC Call*, XJ Gao^, AE Vlahos^.
Perspectives on Synthetic Protein Circuits in Mammalian Cells

XJ Gao, MB Elowitz.
Synthetic biology: Precision timing in a cell
Nature. 2016;538(7626):462-463. (pdf)

XJ Gao.
Drosophila chemotaxis: A first look with neurogenetics
Fly. 2014;8(1):3-6. (pdf)


* denotes equal contribution; ^ denotes corresponding authors; boldface denotes members of Gao Lab.